How is my DNA analysed?

The DNA that was isolated from your saliva sample will be sent to an external partner of Arcensus. There, the sample will be sequenced via Next Generation sequencing (NGS). The order of nucleotides of your entire genome will be revealed. Since NGS technologies are only capable of sequencing small DNA fragments: Your DNA will be initially  sheared into millions of small pieces. Every small piece (‘read’) will be sequenced individually and afterwards, the reads will be aligned together to your initial genome structure. Your final genomic sequence is then compared to the human reference genome to find all the variants in your genome that differ from the reference. According to the product you purchased, the clinically relevant variants will be reported via a medical report.

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